# Leash Bio releases Minos, an AI playground for lab-in-the-loop simulations

Digest AI · Research · published 2026-10-14T20:35:09Z

Canonical: https://digestai.news/story/leash-bio-releases-minos-an-ai-playground-for-lab-in-the-loop-simulati

## Summary

The tool enables agents to perform **verifiable scientific reasoning** using **tens of thousands of lab-in-the-loop simulations** derived from the company’s proprietary data on **DNA Encoded Libraries (DELs)**—a high-throughput method for studying protein-ligand interactions. The project emerged from an earlier AI playground experiment mentioned in a podcast interview with **Ian Quigley**, Leash Bio’s founder, where the team explored how LLMs could analyze **structure-activity relationships (SAR)** in plain English across **6.5 million molecules** with a budget of **100 simulations per molecule**.

## Key points

- Minos enables AI agents to simulate **tens of thousands of lab-in-the-loop experiments** using Leash Bio’s DEL data
- Built on **Hermes**, a model trained only on Leash’s internal datasets, matching public benchmarks like Boltz

## Why it matters

Minos bridges AI and wet-lab biology by validating hypotheses computationally, potentially cutting drug discovery cycles. Its open tools may democratize high-throughput reasoning for researchers outside Leash’s specialized workflows.

## Sources

1. [Lab-in-the-Loop at Compute Speed — Ian Quigley, Leash Bio](https://latent.space/p/lab-in-the-loop-at-compute-speed) (Latent Space, 2026-10-14)

## Cite

Digest AI, "Leash Bio releases Minos, an AI playground for lab-in-the-loop simulations", 14 October 2026, https://digestai.news/story/leash-bio-releases-minos-an-ai-playground-for-lab-in-the-loop-simulati

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