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Google's Co-Scientist proposes gluing condensates to shut down MYC

Biochemist Anna Pertl used Google’s Co‑Scientist to explore ways to silence the cancer‑driving protein MYC. After an hour of prompting, the system scanned more than 700 scientific papers, produced 108 possible strategies and discarded all but one. The surviving idea suggests using click‑chemistry to glue molecular condensates together, creating a mass that blocks MYC’s DNA from being read.

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Key points

  • Co‑Scientist scanned over 700 papers and generated 108 potential MYC‑targeting strategies, keeping only one novel approach.
  • The surviving strategy suggests using click‑chemistry to glue condensate proteins together, blocking MYC transcription.
  • Google built Co‑Scientist; Anthropic, OpenAI, FutureHouse, Phylo, Huawei and Sakana AI also offer AI research‑assistant platforms.

The approach differs from the current effort at Dewpoint Therapeutics, which aims to dissolve the condensates. Overholt, a bioengineer at the Whitehead Institute, called the concept “extremely conceptually compelling.” Co‑Scientist has also been used in earlier projects to identify leukemia‑killing drug combos and liver‑regeneration treatments. Google’s platform joins similar AI research assistants from Anthropic, OpenAI, FutureHouse, Phylo, Huawei and Sakana AI, all of which aim to let scientists focus on framing questions while the AI handles literature synthesis and hypothesis generation.

Experts warn that while AI can accelerate discovery, researchers will need deeper expertise to evaluate AI‑generated ideas. The consensus is that human judgment remains the most valuable asset in the scientific process.

Read the original atNature Machine Learning primary sourceOpen source ↗
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GoogleAnthropicOpenAIFutureHousePhyloDewpoint TherapeuticsAnna PertlRichard YoungKalon OverholtVivek NatarajanAjay AgrawalLe Cong

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